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Fit between the data and the model

Starting from the 2019 version, it is possible to change the fit by default between the data set and the structural model output. Indeed, by default, the fit is done by order, i.e. the first output is linked to the first YTYPE, … now it is possible with then interface to decide exactly which model output is linked with which data output.

Changing the fit

If you have more output in the data set than in the structural model, you can fit which data output you will use in the project. This can come for example if you have several PK, several centers, … In the example below there are two outputs in the data set (managed by the OBSERVATION ID column) and only one output in the structural model Cc. By default you have the following fit

To set the data output to 2, you can either

  • Unlink by clicking on either the dot representing the output 1 of the Data or Cc of the structural model, and draw the line between 2 and Cc (as can be seen on the figure below on the left)
  • Directly draw a line from 2 to Cc (as can be seen on the figure below on the right).

And click on the button ACCEPT on the button on the window

The same possibility is proposed if you have more outputs in the structural model. If you have a TMDD model with both the free and the total ligand concentration and one measurement, you can fit either the free or the total ligand as can be seen on the following figure with the same actions as described below.

Several types of outputs

The fit is only possible between outputs of same nature, i.e. it is only possible to fit a continuous output with a continuous output of the structural model. Thus, fitting a continuous output with a discrete or a time-to-event is not possible.  If you try to link a bad combination, the line connecting line will be displayed in red as in the following figure

To have a clear view of which type is each output,

  • continuous outputs are displayed as circles
  • categorical/count outputs are displayed as squares
  • event outputs are displayed as triangles