Overview
Data
Defining a data set
Data Format
Data formatting
Filtering a data set
Handling censored data
Mapping between data and model
Structural Model
Libraries of models
Writing your own model
Continuous outcomes
Typical PK models
Single route of administration
Multiple routes of administration
Multiple doses to steady-state
Mixture of structural models
Joint models for continuous output
Non-continuous outcomes
Time-to-event data models
Count data model
Categorical data model
Joint models for non continuous outcomes
Extensions
Using a scale factor
Using regression variables
Delayed differential equations
Outputs and Tables
Compute AUC and Cmax
Statistical Model
Overview
Observation (error) model
Individual Model
Overview
Distribution of indiv. param.
Covariate model
Inter-occasion variability
Mixture of distributions
Tasks and results
Overview
Estimation Tasks
Initialization
Initial values and method
Check initial estimates and auto init
Pop. parameters
SAEM
Bayesian estimation or fixed pop. parameters
EBEs
Cond. distribution
Standard errors
Likelihood
Results
Output files
Statistical tests
Proposal
Comments
Cv. assessment
Model building
Overview
Automatic covariate model building
Statistical model building with SAMBA
Projects Comparison in Sycomore
Bootstrap
Plots
Overview
Generating and exporting plots
Interacting with the plots
Export charts data
Data
Observed data
Covariate Viewer
Bivariate Data Viewer
Model for observations
Individual fits
Obs. vs Pred.
Scatter plot of residuals
Distribution of residuals
Model for indiv. param.
Distr. of indiv. param.
Distr. of random effects
Corr. between rand. effects
Indiv. param vs covariates
Predictive checks
Visual predictive check
Numerical predictive check
BLQ predictive check
Prediction distribution
Conv. diagnosis
SAEM
MCMC
Importance sampling
Task results
Likelihood contribution
Stand. errors of estimates
Reporting
Overview
List of reporting keywords
List of plot settings
List of table settings
-functions
R-package installation and initialization
Examples using R functions
List of R functions to run Monolix
Rsmlx
Demos & Case studies
Demo projects
Case studies
FAQ
Frequent Questions
List of known bugs
Feedback
Single page
PDF documentation
Select Page
Bootstrapping – case resampling
Sycomore
Monolix
PKanalix
Dataset
Simulx
Mlxtran
Lixoft University
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